Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins

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Davies, Karen J. and Page, Michael I. (1990) Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins. Chemical Communications (20). pp. 1448-1450. ISSN 1359-7345

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Official URL: http://dx.doi.org/10.1039/C39900001448

DOI: 10.1039/C39900001448

Abstract

The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T–) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T–.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Sharon Beastall
Date Deposited:	06 Nov 2009 10:06
Last Modified:	06 Nov 2009 10:06
URI:	http://eprints.hud.ac.uk/id/eprint/6118

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