The esterase catalysed resolution of lactones and spirodilactone

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Barton, Patrick and Page, Michael I. (1993) The esterase catalysed resolution of lactones and spirodilactone. Journal of the Chemical Society, Perkin Transactions 2 (12). pp. 2317-2318. ISSN 1472-779X

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Official URL: http://dx.doi.org/10.1039/P29930002317

DOI: 10.1039/P29930002317

Abstract

The pig liver esterase catalysed hydrolysis of spirodilactone and -phenyl--butyrolactone gives optically active products (>90% e.e., after 50% reaction). However, the similarly substituted acyclic ester analogues of the lactone do not exhibit enantioselectivity suggesting that the acylation step shows the selectivity. Racemic spirodilactone can be converted, in principle, entirely into one of its enantiomers.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Sharon Beastall
Date Deposited:	06 Nov 2009 08:29
Last Modified:	06 Nov 2009 08:29
URI:	http://eprints.hud.ac.uk/id/eprint/6109

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