Search:
Computing and Library Services - delivering an inspiring information environment

The mechanism of reactions catalysed by the serine β-lactamases

Laws, Andrew P., Page, Michael I. and Slater, Martin J. (1993) The mechanism of reactions catalysed by the serine β-lactamases. Bioorganic & Medicinal Chemistry Letters, 3 (11). pp. 2317-2322. ISSN 0960-894X

Metadata only available from this repository.

Abstract

Nucleophilic substitution at the β-lactam carbonyl of penicillins usually requires general base and acid catalysis and proceeds via the formation of a tetrahedral intermediate. A class C serine β-lactamase is inhibited by phosphonamidates, shows diastereoselectivity in P---O and P---O bond fission and exhibits enzyme catalysed nucleophilic displacement of proline. The requirements for general acid catalysed expulsion of proline have interesting stereochemical consequences.

Necleophilic substitution at the β-lactam carbonyl of penicillins usually requires general base and acid catalysis and proceeds via the formation of a tetrahedral intermediate. A class C serine β-lactamase is inhibited by phosphonamidates, shows diastereoselectivity in P---N and P---O bond fission and exhibits enzyme catalysed nucleophilic displacement of proline. The requirements for general acid catalysed expulsion of proline have interesting stereochemical consequences.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
Related URLs:
Depositing User: Sharon Beastall
Date Deposited: 05 Nov 2009 14:26
Last Modified: 05 Nov 2009 14:26
URI: http://eprints.hud.ac.uk/id/eprint/6105

Item control for Repository Staff only:

View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©