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Esterase catalysed enantioselective ring closure

Barker, C.V., Page, Michael I., Korn, Stewart R. and Monteith, Michael (1999) Esterase catalysed enantioselective ring closure. Chemical Communications (8). pp. 721-722. ISSN 1359-7345

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Porcine liver esterase catalyses the reaction of -amino esters in water to give a mixture of the corresponding -lactam and the hydrolysis product, deacylation of the acyl enzyme intermediate by ring closure occurs with a high enantioselectivity giving an ee of 90% for the formation of (S)-5-phenyl-2-pyrrolidone from racemic ethyl 4-phenyl-4-aminobutanoate

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sharon Beastall
Date Deposited: 05 Nov 2009 12:23
Last Modified: 05 Nov 2009 12:23


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