A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

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Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1998) A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction. Tetrahedron Letters, 39 (27). pp. 4905-4908. ISSN 0040-4039

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Official URL: http://dx.doi.org/10.1016/S0040-4039(98)00892-2

DOI: 10.1016/S0040-4039(98)00892-2

Abstract

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Sharon Beastall
Date Deposited:	05 Nov 2009 10:42
Last Modified:	05 Nov 2009 10:45
URI:	http://eprints.hud.ac.uk/id/eprint/6087

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