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A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1998) A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction. Tetrahedron Letters, 39 (27). pp. 4905-4908. ISSN 0040-4039

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Abstract

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sharon Beastall
Date Deposited: 05 Nov 2009 10:42
Last Modified: 05 Nov 2009 10:45
URI: http://eprints.hud.ac.uk/id/eprint/6087

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