Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1999) A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives. Tetrahedron Letters, 40 (1). pp. 143-146. ISSN 0040-4039Metadata only available from this repository.
A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane as hydride source generates the targets with up to exclusive levels of diastereoselectivity. This approach compliments that reported in the preceding paper.
|Subjects:||Q Science > Q Science (General)|
|Schools:||School of Applied Sciences|
|Depositing User:||Sharon Beastall|
|Date Deposited:||04 Nov 2009 12:31|
|Last Modified:||04 Nov 2009 12:31|
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