A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1999) A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives. Tetrahedron Letters, 40 (1). pp. 143-146. ISSN 0040-4039

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Abstract

A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane as hydride source generates the targets with up to exclusive levels of diastereoselectivity. This approach compliments that reported in the preceding paper.

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URI:

https://eprints.hud.ac.uk/id/eprint/6076

URI:

https://eprints.hud.ac.uk/id/eprint/6076

Title:

A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives

Creators:

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z.

Identification Number:

https://doi.org/10.1016/S0040-4039(98)80042-7

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