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The Challenge of Atropisomerism in Drug Discovery

Clayden, Jonathan, Moran, Wesley J., Edwards, Paul J. and LaPlante, Steven R. (2009) The Challenge of Atropisomerism in Drug Discovery. Angewandte Chemie International Edition, 48 (35). pp. 6398-6401. ISSN 14337851

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Abstract

A twist in the tale: Recent reports have highlighted solutions to the problems encountered when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme). This Minireview brings together the various strategies that have been adopted and proposes a general approach to handling an aspect of stereochemistry which has received little attention from drug regulatory agencies.

Item Type: Article
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
School of Applied Sciences > Biomolecular Sciences Research Centre
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Depositing User: Graham Stone
Date Deposited: 25 Aug 2009 12:12
Last Modified: 25 Aug 2009 12:12
URI: http://eprints.hud.ac.uk/id/eprint/5453

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