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A case control investigation of the relation between hyperlipidaemia and calcific aortic valve stenosis

Wilmshurst, P T, Stevenson, R N, Griffiths, H and Lord, John R (1997) A case control investigation of the relation between hyperlipidaemia and calcific aortic valve stenosis. Heart, 78. pp. 475-479. ISSN 1355-6037

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    Abstract

    Objective To investigate the relation of hyperlipidaemia to calcific aortic valve stenosis.
    Design A case-control study designed to detect a clinically relevant difference in the fasting plasma concentrations of total cholesterol between the groups at the 5% level with a power of 90%. Predefined subgroup analyses were based on presence of significant coronary disease and valve morphology (that is, bicuspid or tricuspid).
    Setting A district general hospital.
    Subjects 20 patients with severe calcific aortic stenosis and 20 controls.
    Results Mean (SD) fasting plasma total cholesterol in patients with aortic stenosis was 0.79 (1.50) mmol/l greater than in the controls (p = 0.029). The magnitude of differences between patients with aortic stenosis and controls was similar whether the patients had coronary artery disease (0.78 (1.73) mmol/l) or not (0.80 (1.37) mmol/l). The presence of a stenosed tricuspid aortic valve was associated with a significant increase in plasma cholesterol (1.70 (0.87) mmol/l, p = 0.012). For bicuspid valves the degree of elevation of plasma cholesterol was less and not statistically significant.
    Conclusions Calcific aortic stenosis is associated with hypercholesterolaemia, especially when the valve is tricuspid. Further studies are necessary to confirm that the relation is causal. This finding may have implications for measures to prevent the most common cause of cardiac valve replacement in the developed world.

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    Item Type: Article
    Additional Information: Reproduced with kind permission from the BMJ Publishing Group
    Uncontrolled Keywords: calcific aortic stenosis hypercholesterolaemia hyperlipidaemia
    Subjects: R Medicine > RC Internal medicine
    Schools: School of Human and Health Sciences
    School of Human and Health Sciences > Centre for Health and Social Care Research
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    Depositing User: John Lord
    Date Deposited: 13 Jul 2009 11:07
    Last Modified: 06 Jan 2011 18:18
    URI: http://eprints.hud.ac.uk/id/eprint/4426

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