Dolmans, G.H. and Hennies, Hans C. (2011) The genetic basis of Dupuytren's disease. In: Morbus Dupuytren and related hyperproliferative disorders. Springer, Heidelberg, pp. 89-91. ISBN 978-3-642-22696-0Metadata only available from this repository.
Dupuytren’s disease is a multifactorial disorder. Twin studies and familial studies have demonstrated a strong genetic component for Dupuytren’s disease. An autosomal dominant mode of inheritance with reduced penetrance has been suggested; however, a gene involved in Dupuytren’s disease using a family-based gene mapping approach has not been identified so far. Therefore we have embarked on a genome-wide association study to identify susceptibility genes for Dupuytren’s disease. Here we give a brief introduction into molecular studies of multifactorial disorders and describe basic approaches used in these studies. Based on recent findings concerning the genetics of Dupuytren’s disease, we explain the rationale for our approach and the conclusions that could be expected from the work. Additionally, this chapter may serve as a brief introduction into the genetic studies in Dupuytren’s disease.
|Item Type:||Book Chapter|
|Additional Information:||Unmapped bibliographic data: ST - The genetic basis of Dupuytren's disease [Field not mapped to EPrints] LB - 103 [Field not mapped to EPrints] RP - Not in File [Field not mapped to EPrints]|
|Subjects:||Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RD Surgery
|Schools:||School of Applied Sciences|
|Depositing User:||Hans Hennies|
|Date Deposited:||11 Jul 2016 14:24|
|Last Modified:||29 Jul 2016 13:11|
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