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Predicting human intestinal absorption in the presence of bile salt with micellar liquid chromatography

Waters, Laura J., Shokry, Dina and Parkes, Gareth M.B (2016) Predicting human intestinal absorption in the presence of bile salt with micellar liquid chromatography. Biomedical Chromatography. ISSN 1099-0801

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Understanding intestinal absorption for pharmaceutical compounds is vital to estimate bioavailability and therefore the in vivo potential of a drug. This study considers the application of micellar liquid chromatography (MLC) to predict passive intestinal absorption with a selection of model compounds. MLC is already known to aid prediction of absorption using simple surfactant systems however, with this study the focus was on the presence of a more complex, bile salt surfactant, as would be encountered in the in vivo environment. As a result, MLC using a specific bile salt has been confirmed as an ideal in vitro system to predict the intestinal permeability for a wide range of drugs, through the development of a quantitative partition-absorption relationship. MLC offers many benefits including environmental, economic, time-saving and ethical advantages compared with the traditional techniques employed to obtain passive intestinal absorption values.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
Related URLs:
Depositing User: Laura Waters
Date Deposited: 05 Apr 2016 08:27
Last Modified: 05 Apr 2016 08:29


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