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An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

Adebisi, Adeola O., Kaialy, Waseem, Hussain, Tariq, Al-Hamidi, Hiba, Nokhodchi, Ali, Conway, Barbara R. and Asare-Addo, Kofi (2016) An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine. Powder Technology, 292. pp. 342-350. ISSN 00325910

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Abstract

One of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forces during the grinding process can lead to changes in the physicochemical characteristics as well as an increase in the surface free energy of the ground particles, which causes an alteration in the electrostatic properties of these particles. The solid state characteristics of glucosamine hydrochloride (GLU) and carbamazepine (CBZ) and their co-ground mixtures were studied using DSC, XRPD and SEM. These revealed that polymorphic transformations occurred due to the grinding process. The influence of grinding time on the triboelectrification properties of the formulations was also studied. Both pure CBZ and GLU powders were predominantly electro-positively charged and their charging properties increased with increasing grinding time. CBZ:GLU physical mixtures exhibited complicated bipolar charging behaviour, however, when subjected to grinding, these mixtures demonstrated mainly electronegative charge properties. The influence of both grinding time and CBZ content within CBZ:GLU mixtures were examined. The value of net-electronegative-charge density of CBZ:GLU mixtures was shown to increase with grinding time and /or when increasing the percentage proportion of CBZ up to 30 % w:w. This study helps to provide information about the handling of these formulation and gives a formulator tools to ascertain appropriate ratios for handling and possible simultaneous dissolution improvements.

Item Type: Article
Additional Information: Abbreviations: GLU, glucosamine hydrochloride; DSC, differential scanning calorimetry; XRPD, x-ray powder diffraction; BCS, biopharmaceutical classification system; CBZ, carbamazepine; SEM, scanning electron microscopy; RH, relative humidity; PSD, particle size distribution; PM, physical mixture.
Uncontrolled Keywords: Electrostatics; Solid dispersions; Triboelectrification; Carbamazepine; D-glucosamine HCl; Polymorphism
Subjects: Q Science > Q Science (General)
Schools: School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
Depositing User: Kofi Asare-Addo
Date Deposited: 23 Feb 2016 13:22
Last Modified: 29 Mar 2016 20:26
URI: http://eprints.hud.ac.uk/id/eprint/27282

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