Computing and Library Services - delivering an inspiring information environment

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Nep, E.I., Asare-Addo, Kofi, Ghori, Muhammad U., Conway, Barbara R and Smith, Alan M. (2015) Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour. International Journal of Pharmaceutics, 496 (2). pp. 689-698. ISSN 03785173

[img] PDF - Accepted Version
Restricted to Repository staff only until 1 November 2016.

Download (987kB)


Polysaccharides are suitable for application as hydrophilic matrices because of their ability to hydrate and swell upon contact with fluids, forming a gel layer which controls drug release. When extracted from plants, polysaccharides often contain significant quantities of starch that impacts upon their functional properties. This study aimed to evaluate differences in swelling, erosion and drug release from matrix tablets prepared from grewia gum (GG) and starch-free grewia gum (GDS) extracted from the stems of Grewia mollis. HPMC was used as a control polymer with theophylline as a model drug. Swelling, erosion, and in-vitro release were performed in deionized water, pH1.2 and pH6.8 media. The Vergnaud and Krosmeyer-Peppas model were used for swelling and drug release kinetics, respectively. However, linear regression technique was used to determine the erosion rate. GDS compacts were significantly harder than the native GG and HPMC compacts. GDS matrices exhibited the fastest erosion and drug release in deionised water and phosphate buffer compared with the GG and HPMC. At pH1.2, GDS exhibited greater swelling than erosion, and drug release was similar to GG and HPMC. This highlights the potential of GDS as a matrix for controlled release similar to HPMC and GG at pH1.2 but with a more rapid release at pH6.8. GDS may have wider application in reinforcing compacts with relatively low mechanical strength

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
Related URLs:
Depositing User: Sara Taylor
Date Deposited: 17 Nov 2015 13:12
Last Modified: 20 Apr 2016 17:40


Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©