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Parallel Selection Mapping Using Artificially Selected Mice Reveals Body Weight Control Loci

Chan, Yingguang Frank, Jones, Felicity C., McConnell, Ellen, Bryk, Jarek, Bünger, Lutz and Tautz, Diethard (2012) Parallel Selection Mapping Using Artificially Selected Mice Reveals Body Weight Control Loci. Current Biology, 22 (9). pp. 794-800. ISSN 09609822

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Understanding how polygenic traits evolve under selection is an unsolved problem [1], because challenges exist for identifying genes underlying a complex trait and understanding how multilocus selection operates in the genome. Here we study polygenic response to selection using artificial selection experiments. Inbred strains from seven independent long-term selection experiments for extreme mouse body weight (“high” lines weigh 42–77 g versus 16–40 g in “control” lines) [2] were genotyped at 527,572 SNPs to identify loci controlling body weight. We identified 67 parallel selected regions (PSRs) where high lines share variants rarely found among the controls. By comparing allele frequencies in one selection experiment [2, 3 and 4] against its unselected control, we found classical selective sweeps centered on the PSRs. We present evidence supporting two G protein-coupled receptors GPR133 and Prlhr as positional candidates controlling body weight. Artificial selection may mimic natural selection in the wild: compared to control loci, we detected reduced heterozygosity in PSRs in unusually large wild mice on islands. Many PSRs overlap loci associated with human height variation [ 5], possibly through evolutionary conserved functional pathways. Our data suggest that parallel selection on complex traits may evoke parallel responses at many genes involved in diverse but relevant pathways

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QH Natural history > QH426 Genetics
Schools: School of Applied Sciences
Related URLs:
Depositing User: Sara Taylor
Date Deposited: 08 Sep 2015 15:10
Last Modified: 08 Sep 2015 15:10


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