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Modification of drug delivery to improve antibiotic targeting to the stomach

Adebisi, Adeola O. and Conway, Barbara R (2015) Modification of drug delivery to improve antibiotic targeting to the stomach. Therapeutic Delivery, 6 (6). pp. 741-762. ISSN 2041-5990

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Abstract

The obstacles to the successful eradication of Helicobacter pylori infections include the presence of antibiotic-resistant bacteria and therapy requiring multiple drugs with complicated dosing schedules. Other obstacles include bacterial residence in an environment where high antibiotic concentrations are difficult to achieve. Biofilm production by the bacteria is an additional challenge to the effective treatment of this infection. Conventional oral formulations used in the treatment of this infection have a short gastric residence time, thus limiting the duration of exposure of drug to the bacteria. This review summarizes the current research in the development of gastroretentive formulations and the prospective future applications of this approach in the targeted delivery of drugs such as antibiotics to the stomach.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
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Depositing User: Sara Taylor
Date Deposited: 14 Jul 2015 14:13
Last Modified: 29 Mar 2016 15:19
URI: http://eprints.hud.ac.uk/id/eprint/25081

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