Aitken, R.A., Bibby, M.C., Double, J.A., Phillips, Roger M. and Sharma, S.K. (1996) Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 1: 6-Methyl derivatives. Archiv der Pharmazie, 329 (11). pp. 489-497.Metadata only available from this repository.
A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.
|Subjects:||R Medicine > RM Therapeutics. Pharmacology|
|Schools:||School of Applied Sciences|
|Depositing User:||Roger Phillips|
|Date Deposited:||13 May 2015 09:59|
|Last Modified:||13 May 2015 09:59|
Downloads per month over past year
Repository Staff Only: item control page