Almodares, Zahra, Lucas, Stephanie J., Crossley, Benjamin D., Basri, Aida M., Pask, Christopher M., Hebden, Andrew J., Phillips, Roger M. and McGowan, Patrick C. (2014) Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents. Inorganic Chemistry, 53 (2). pp. 727-736. ISSN 0020-1669Metadata only available from this repository.
Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
|Subjects:||R Medicine > RM Therapeutics. Pharmacology|
|Schools:||School of Applied Sciences|
|Depositing User:||Roger Phillips|
|Date Deposited:||12 May 2015 14:17|
|Last Modified:||14 May 2015 10:58|
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