Alhalib, Ali (2015) Cyclisation of Propargyl and Allyl Amides: Syntheses of Oxazolines. Doctoral thesis, University of Huddersfield.
- Accepted Version
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This thesis describes several approaches to the synthesis of dihydrooxazoles (oxazolines) by
the cyclisation of unsaturated amides.
The first major approach to the synthesis of substituted dihydrooxazoles is the CuI-catalysed
cycloisomerisation of terminal propargyl amides. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Substrates containing a benzylic methylene were oxidised to the ketone under the reaction conditions.
The second major focus of this thesis is the cyclisation of N-alkenylamides catalysed by
iodoarenes under oxidative conditions. Dihydrooxazoles were prepared by this route with a
range of substitution patterns in good yields.
|Item Type:||Thesis (Doctoral)|
|Subjects:||Q Science > QD Chemistry|
|Schools:||School of Applied Sciences|
|Depositing User:||Elizabeth Boulton|
|Date Deposited:||20 Apr 2015 11:47|
|Last Modified:||12 Dec 2016 16:54|
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