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Triboelectrification and dissolution property enhancements of solid dispersions

Asare-Addo, Kofi, Šupuk, Enes, Al-Hamidi, Hiba, Owusu-Ware, Samuel, Nokhodchi, Ali and Conway, Barbara R (2015) Triboelectrification and dissolution property enhancements of solid dispersions. International Journal of Pharmaceutics, 485 (1/2). pp. 306-316. ISSN 03785173

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The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles. Particle triboelectrification plays an important part in powder processing, affecting end product quality due to particle deposition and powder loss. This study investigates the use of glucosamine hydrochloride (GLU) in solid dispersions with indomethacin. Solvents selected for the preparation of the dispersions were acetone, acetone–water, ethanol and ethanol–water. Solid state characterizations (DSC, FTIR and XRPD) and dissolution were conducted. Dispersions were subjected to charge using a custom built device based on a shaking concept, consisting of a Faraday cup connected to an electrometer. All dispersions improved the dissolution rate of indomethacin. Analysis showed the method of preparation of the dispersion induced polymorphic forms of the drug. Indomethacin had a high propensity for charging (−411 nC/g). GLU had a very low charge (−1 nC/g). All dispersions had low charges (−1 to 14 nC/g). Acetone as a solvent, or in combination with water, produced samples with an electronegative charge in polarity. The same approach with ethanol produced electropositive charging. The results show the selection of solvents can influence powder charge thereby improving powder handling as well as dissolution properties.

Item Type: Article
Uncontrolled Keywords: Electrostatics; Solid dispersions; Tribo electrification; Indomethacin; D-glucosamine HCl; Polymorphism
Subjects: Q Science > Q Science (General)
Schools: School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
Depositing User: Kofi Asare-Addo
Date Deposited: 07 Apr 2015 15:14
Last Modified: 30 Mar 2016 02:43


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