Search:
Computing and Library Services - delivering an inspiring information environment

A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR

Garelnabi, EAE, Pletsas, D, Li, L, Kiakos, K, Karodia, N, Hartley, JA, Phillips, Roger and Wheelhouse, RT (2012) A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR. ACS Medicinal Chemistry Letters, 3 (12). pp. 965-968. ISSN 1948-5875

[img] PDF - Accepted Version
Download (304kB)
[img] Microsoft Word - Accepted Version
Restricted to Repository staff only

Download (520kB)

Abstract

The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The new compounds are potent DNA alkylators and have antitumor activity independent of the O6-methylguanine-DNA methyltransferase and DNA mismatch repair constraints that limit the use of temozolomide.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
Related URLs:
Depositing User: Roger Phillips
Date Deposited: 26 Feb 2015 16:45
Last Modified: 02 Dec 2016 10:25
URI: http://eprints.hud.ac.uk/id/eprint/23499

Downloads

Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©