Search:
Computing and Library Services - delivering an inspiring information environment

The use of high performance anion exchange chromatography for the detection of counterfeit pharmaceutical products using the excipient content as a marker

Beasley, Emma, Suman, Mandeesh and Coleman, Tyler (2015) The use of high performance anion exchange chromatography for the detection of counterfeit pharmaceutical products using the excipient content as a marker. Fields: journal of Huddersfield student research, 1 (1). e4. ISSN 2057-0163

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (430kB)

Abstract

The aim of the investigation described here was to examine the differences between genuine and counterfeit pharmaceutical products through the development of an analytical method capable of rigorously identifying the sugar-based excipients. High Performance Anion Exchange Chromatography, coupled to Pulsed Amperometric Detection (HPAEC-PAD), supported by Gas Chromatography-Mass Spectrometry (GC-MS), provided a method for the analysis of the carbohydrate based excipients. The analytical method was able to discriminate between the substitution patterns of a number of monosaccharides derived from commonly used excipients and these were compared for both genuine and counterfeit sildenafil citrate based products. The aim of the project was accomplished: the HPAEC-method was employed to analyse a counterfeit pharmaceutical ‘Herbal Viagra’.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: Cherry Edmunds
Date Deposited: 22 Jan 2015 10:17
Last Modified: 07 Dec 2016 02:01
URI: http://eprints.hud.ac.uk/id/eprint/23152

Downloads

Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©