Adebisi, Adeola O., Laity, Peter R. and Conway, Barbara R (2015) Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori. Journal of Pharmacy and Pharmacology, 67 (4). pp. 511-524. ISSN 0022-3573
- Submitted Version
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection. This study describes the preparation and characterisation of novel floating-mucoadhesive alginate beads loaded with clarithromycin (CMN) for delivery to the gastric mucosa to improve the eradication of this micro-organism.
Methods: Calcium alginate beads were prepared by ionotropic gelation. The formulation was modified through addition of oil and coating with chitosan in order to improve floating, mucoadhesion and modify drug release.
Key findings: SEM confirmed the sphericity of the beads with X-ray microtomography (XμMT) showing the 3D structure of the beads with the layered internal structure of the bead and the even distribution of the drug within the bead. This formulation combined two gastro-retentive strategies and these formulations produced excellent in vitro floating, mucoadhesive and drug release characteristics. Enhanced stability of the beads in phosphate buffer raises a potential for the modified formulations to be targeted to regions of higher pH within the gastrointestinal tract with a higher pH. Drug release from these beads was sustained through an unstirred mucin layer simulating in vivo conditions under which the H. pylori resides in the gastric mucosa.
Conclusions: This novel formulation will ensure retention for a longer period in the stomach than conventional formulations and control drug release, ensuring high local drug concentrations, leading to improved eradication of the bacteria.
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
|Schools:||School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
|Depositing User:||Sara Taylor|
|Date Deposited:||08 Jan 2015 09:35|
|Last Modified:||31 Mar 2016 08:36|
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