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Bounaga, Sakina, Galleni, Moreno, Laws, Andrew P. and Page, Michael I. (2001) Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase. Bioorganic & Medicinal Chemistry Letters, 9 (2). pp. 503-507. ISSN 0960-894X
Metadata only available from this repository.Official URL: http://dx.doi.org/10.1016/S0968-0896(00)00257-1
Abstract
Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-β-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). , -Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Schools: | School of Applied Sciences School of Applied Sciences > Biomolecular Sciences Research Centre |
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| Depositing User: | Sara Taylor |
| Date Deposited: | 17 Oct 2008 12:13 |
| Last Modified: | 20 Oct 2008 10:23 |
| URI: | http://eprints.hud.ac.uk/id/eprint/2267 |
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