Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (2000) Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives. Journal of the Chemical Society Perkin Transactions 1 (11). pp. 1715-1721. ISSN 14727781Metadata only available from this repository.
New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application
of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles.
Removal of the phenylglycinol derived chiral auxiliary can be achieved without loss of stereochemical integrity at
the newly created asymmetric centre, and we report a novel method for this key step using conc. sulfuric acid.
|Subjects:||Q Science > Q Science (General)|
Q Science > QD Chemistry
|Schools:||School of Applied Sciences|
School of Applied Sciences > Biomolecular Sciences Research Centre
|Depositing User:||Sara Taylor|
|Date Deposited:||17 Oct 2008 11:58|
|Last Modified:||20 Oct 2008 10:16|
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