The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

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Page, Michael I. and Laws, Andrew P. (2000) The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams. Tetrahedron, 56 (31). pp. 5631-5637. ISSN 0040-4020

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Official URL: http://dx.doi.org/10.1016/S0040-4020(00)00412-9

DOI: 10.1016/S0040-4020(00)00412-9

Abstract

β-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of β-sultams and β-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Schools:	School of Applied Sciences School of Applied Sciences > Biomolecular Sciences Research Centre
Related URLs:	Author Author
Depositing User:	Sara Taylor
Date Deposited:	16 Oct 2008 16:44
Last Modified:	20 Oct 2008 09:26
URI:	http://eprints.hud.ac.uk/id/eprint/2259

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