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Hemming, Karl, Bevan, Matthew J., Loukou, Christina, Patel, Snahal D. and Renaudeau, Denis (2000) A One-Pot Aza-Wittig Based Solution and Polymer Supported Route to Amines. Synlett, 2000 (11). pp. 1565-1568. ISSN 09365214
Metadata only available from this repository.Abstract
This paper presents a high yielding one-pot solution phase and polymer supported synthesis of a range of primary and secondary amines starting from azides and aldehydes. The synthesis utilises a tandem process which begins with an aza-Wittig reaction between the aldehyde and an iminophosphorane, followed by reduction, or organometallic 1,2-addition reaction, of the resultant imine. The requisite iminophosphoranes were accessed using the highly efficient Staudinger reaction between the azide starting material and a phosphine. The process was applicable to the solid phase by the use of polymer supported iminophosphoranes and polymer supported cyanoborohydride
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Schools: | School of Applied Sciences School of Applied Sciences > Biomolecular Sciences Research Centre |
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| Depositing User: | Sara Taylor |
| Date Deposited: | 16 Oct 2008 12:21 |
| Last Modified: | 17 Oct 2008 16:28 |
| URI: | http://eprints.hud.ac.uk/id/eprint/2248 |
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