A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines

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Anwar, Balques, Grimsey, Paul, Hemming, Karl, Krajniewski, Matthew and Loukou, Christina (2000) A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines. Tetrahedron Letters, 41 (51). pp. 10107-10110. ISSN 0040-4039

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Official URL: http://dx.doi.org/10.1016/S0040-4039(00)01797-4

DOI: 10.1016/S0040-4039(00)01797-4

Abstract

A new approach to the synthesis of imine containing 1,2,5-benzothiadiazepine-1,1-dioxides and 1,4-benzodiazepin-5-ones using iminophosphoranyl thiazine-S-oxides as precursors is reported. Key steps include a Staudinger reaction, an aza-Wittig reaction and the conversion of a thiazine-S-oxide into an amino ketone via a [2,3] sigmatropic rearrangement

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Schools:	School of Applied Sciences School of Applied Sciences > Biomolecular Sciences Research Centre
Related URLs:	Author
Depositing User:	Sara Taylor
Date Deposited:	16 Oct 2008 12:15
Last Modified:	17 Oct 2008 16:28
URI:	http://eprints.hud.ac.uk/id/eprint/2247

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