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Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

Elmekawy, A. A., Sweeney, J. B. and Brown, D.R. (2015) Efficient synthesis of supported proline catalysts for asymmetric aldol reactions. Catalysis Science & Technology, 5 (2). pp. 690-696. ISSN 2044-4753

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Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sharon Beastall
Date Deposited: 24 Sep 2014 07:58
Last Modified: 17 Mar 2015 14:20


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