Macaulay, Vincent, Richards, Martin B., Hickey, Eileen, Vega, Emilce, Cruciani, Fulvio, Guida, Valentina, Scozzari, Rosaria, Bonné-Tamir, Batsheva, Sykes, Bryan and Torroni, Antonio (1999) The Emerging Tree of West Eurasian mtDNAs: A Synthesis of Control-Region Sequences and RFLPs. The American Journal of Human Genetics, 64 (1). pp. 232-249. ISSN 0002-9297Metadata only available from this repository.
Variation in the human mitochondrial genome (mtDNA) is now routinely described and used to infer the histories of peoples, by means of one of two procedures, namely, the assaying of RFLPs throughout the genome and the sequencing of parts of the control region (CR). Using 95 samples from the Near East and northwest Caucasus, we present an analysis based on both systems, demonstrate their concordance, and, using additional available information, present the most refined phylogeny to date of west Eurasian mtDNA. We describe and apply a nomenclature for mtDNA clusters. Hypervariable nucleotides are identified, and the relative mutation rates of the two systems are evaluated. We point out where ambiguities remain. The identification of signature mutations for each cluster leads us to apply a hierarchical scheme for determining the cluster composition of a sample of Berber speakers, previously analyzed only for CR variation. We show that the main indigenous North African cluster is a sister group to the most ancient cluster of European mtDNAs, from which it diverged ∼50,000 years ago.
|Subjects:||D History General and Old World > D History (General) > D051 Ancient History
D History General and Old World > D History (General) > D901 Europe (General)
Q Science > Q Science (General)
Q Science > QH Natural history > QH426 Genetics
|Schools:||School of Applied Sciences|
|Depositing User:||Sara Taylor|
|Date Deposited:||07 Aug 2014 10:49|
|Last Modified:||07 Aug 2014 10:49|
Downloads per month over past year
Repository Staff Only: item control page