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Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level

Wright, Josephine A., McHugh, Patrick C, Pan, Siyi, Cunningham, Adam and Brown, David .R. (2013) Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level. Molecular and Cellular Neuroscience, 57. pp. 33-41. ISSN 1044-7431

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Abstract

Alpha-synuclein is a cytosolic protein associated with a range of diseases including Parkinson's disease. In these diseases alpha-synuclein aggregates and this is believed to play a causative role in disease progression. Alpha-synuclein aggregation has been suggested to be caused by increased expression levels and has also been suggested to be countered by increased beta-synuclein expression. In this regard, strategies to counter-regulate the expression of the synucleins by increasing beta-synuclein expression relative to alpha-synuclein may be beneficial in preventing disease progression. We therefore studied the regulation of alpha-synuclein to try to identify pathways that might counter-regulate the synucleins. We identified members of the ZSCAN family of transcription factors as specific repressors of alpha-synuclein. In particular ZSCAN21 was found to both repress alpha-synuclein and increase beta-synuclein expression. These findings support the notion that a single pathway in the cell can counter-regulate the expression of the synucleins. Support for this came from experiments that showed that ZSCAN21 expression decreases alpha-synuclein aggregation in the cells.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Related URLs:
Depositing User: Cherry Edmunds
Date Deposited: 28 Jan 2014 14:59
Last Modified: 17 Mar 2014 11:00
URI: http://eprints.hud.ac.uk/id/eprint/19539

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