Šupuk, Enes, Ghori, Muhammad U., Asare-Addo, Kofi, Laity, Peter R., Panchmatia, Pooja M. and Conway, Barbara R (2013) The influence of salt formation on electrostatic and compression properties of flurbiprofen salts. International Journal of Pharmaceutics, 458 (1). pp. 118-127. ISSN 0378-5173
- Accepted Version
- Accepted Version
- Accepted Version
Salt formation is an effective method of improving physicochemical properties of acidic and basic drugs. The selection of a salt form most suitable for drug development requires a well-designed screening strategy to ensure various issues are addressed in the early development stages. Triboelectrification of pharmaceutical powders may cause problems during processing such as segregation of components due to the effects of particle adhesion. However, very little work has been done on the effect of salt formation on triboelectrification properties. In this paper, salts of flurbiprofen were prepared by combining the drug with a selection of closely related amine counter ions. The aim of the work was to investigate the impact of the counter ion on electrostatic charge of the resultant salts to inform the salt selection process. The experimental results show the magnitude of charge and polarity of the flurbiprofen salts to be highly dependent on the type of counter ion selected for the salt formation. Furthermore, particle adhesion to the stainless steel surface of the shaking container and the salts’ compression properties were measured. The formed salts had lower electrostatic charges, improved tabletability, and resulted in reduced adhesion of these powders compared with the parent drug.▼ Jump to Download Statistics
|Uncontrolled Keywords:||Pharmaceutical Electrostatics Tribo-electrification Flurbiprofen|
|Subjects:||Q Science > Q Science (General)
Q Science > QC Physics
Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
|Schools:||School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
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|Depositing User:||Enes Supuk|
|Date Deposited:||29 Oct 2013 11:11|
|Last Modified:||30 Apr 2017 07:51|
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