Powles, Nicholas and Mistry, Dharmit (2013) The Relative Hydrolytic Reactivities of Pyrophosphites and Pyrophosphates. Organic & Biomolecular Chemistry. ISSN 1477-0520
- Published Version
Available under License Creative Commons Attribution.
The pH-rate profiles for the hydrolysis of pyrophosphate (PP(V)) and pyrophosphite (PP(III), pyro-di-H-phosphonate) are a complex function of pH, reflecting the different ionic species and their relative reactivities. PP(III) is more reactive than PP(V) at all pHs and only PP(III) shows a hydroxide-ion reaction at high pH, so it is 1010-fold more reactive than PP(V) in 0.1 M NaOH. The pKa2 of PP(III) [similar]0.44, so the dominant species at pH's > 1 is the di-anion PP(III)2−. Although there is no observable (NMR or ITC) binding of Mg2+ to the PP(III) di-anion there is a modest increase in the rate of hydrolysis of PP(III) by Mg2+. PP(III) is neither a substrate nor an inhibitor of pyrophosphatase, the enzyme that efficiently catalyses the hydrolysis of PP(V).
|Subjects:||Q Science > QD Chemistry|
|Schools:||School of Applied Sciences|
|Depositing User:||Cherry Edmunds|
|Date Deposited:||26 Jul 2013 08:36|
|Last Modified:||04 Nov 2015 23:31|
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