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Preparation and characterisation of gastroretentive alginate beads for targeting H. pylori

Adebisi, Adeola O. and Conway, Barbara R (2014) Preparation and characterisation of gastroretentive alginate beads for targeting H. pylori. Journal of Microencapsulation, 31 (1). pp. 58-67. ISSN 0265-2048

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Abstract

There are various obstacles in the eradication of Helicobacter pylori (H. pylori) infections including low drug levels due to short gastric residence times and poor accessibility of the drug at the site of the infection. In this study, calcium alginate beads containing metronidazole were prepared by ionotropic gelation with diameters ranging from 2 to 3 mm and bulk densities ranging from 0.11 to 0.23 g/cm3. These beads failed buoyancy tests and released the drug rapidly. The formulation was modified in order to improve floating and modify their drug release profile through addition of oil and coating with chitosan. Upon modification, buoyancy improved and drug release was sustained. This novel formulation will ensure retention for a longer period in the stomach and control the release of drug, ensuring high local drug concentrations, leading to improved eradication of the bacteria.

Read More: http://informahealthcare.com.libaccess.hud.ac.uk/doi/abs/10.3109/02652048.2013.805840

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
Related URLs:
Depositing User: Barbara Conway
Date Deposited: 02 Jul 2013 13:12
Last Modified: 29 Mar 2016 15:06
URI: http://eprints.hud.ac.uk/id/eprint/17847

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