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A Robust First-Pass Protocol for the Heck–Mizoroki Reaction

Murray, Paul M., Bower, John F., Cox, David K., Galbraith, Ewan K., Parker, Jeremy S. and Sweeney, Joseph B. (2013) A Robust First-Pass Protocol for the Heck–Mizoroki Reaction. Organic Process Research & Development, 17 (3). pp. 397-405. ISSN 1083-6160

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Abstract

The Heck–Mizoroki (HM) reaction is one of the most widely used C–C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.

Item Type: Article
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Joseph Sweeney
Date Deposited: 01 May 2013 08:49
Last Modified: 01 May 2013 08:49
URI: http://eprints.hud.ac.uk/id/eprint/17275

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