Search:
Computing and Library Services - delivering an inspiring information environment

Digluconate and Isopropyl Alcohol Biocide Formulation

Hendry, E. R., Conway, Barbara R. and Worthington, T. (2012) Digluconate and Isopropyl Alcohol Biocide Formulation. International Journal of Molecular Sciences, 13 (11). pp. 14016-14025. ISSN 1422-0067

[img]
Preview
PDF - Published Version
Download (182kB) | Preview

    Abstract

    Effective surface disinfection is a fundamental infection control strategy within healthcare. This study assessed the antimicrobial efficacy of novel biocide formulations comprising 5% and 2% eucalyptus oil (EO) combined with 2% chlorhexidine digluconate (CHG) and 70% isopropyl alcohol (IPA) contained within a wipe. The efficacy of this novel antimicrobial formulation to remove and eliminate methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Candida albicans from steel surfaces was investigated. Adpression studies of pre-contaminated wipes were also utilised to assess their potential to induce cross-contamination between hard surfaces. Furthermore, the bactericidal nature of the EO-formulation was established in addition to time-kill. The EO-containing formulations demonstrated bactericidal antimicrobial efficacy against all microorganisms and did not induce surface cross-contamination. There was no significant difference (p < 0.05) between the 5% and 2% EO formulations in their ability to remove microorganisms from steel surfaces, however both significantly (p < 0.05) removed more than the control formulations. Microbial biofilms were eliminated within 10 min (p < 0.05) when exposed to the EO formulations. Our novel EO-formulation demonstrated rapid antimicrobial efficacy for potential disinfection and elimination of microbial biofilms from hard surfaces and may therefore be a useful adjunct to current infection control strategies currently employed within healthcare facilities.

    Item Type: Article
    Subjects: R Medicine > RM Therapeutics. Pharmacology
    Schools: School of Applied Sciences
    Related URLs:
    Depositing User: Barbara Conway
    Date Deposited: 12 Nov 2012 12:18
    Last Modified: 12 Nov 2012 12:18
    URI: http://eprints.hud.ac.uk/id/eprint/15821

    Document Downloads

    Downloader Countries

    More statistics for this item...

    Item control for Repository Staff only:

    View Item

    University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©