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An Investigation of the Cause of Low Variability on the Fourth Chromosome of Drosophila melanogaster

Carr, Martin, Soloway, Judith R., Robinson, Thelma E. and Brookfield, John F. (2001) An Investigation of the Cause of Low Variability on the Fourth Chromosome of Drosophila melanogaster. Molecular Biology and Evolution, 18 (12). pp. 2260-2269. ISSN 0737-4038

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Abstract

The fourth chromosome of Drosophila melanogaster lacks meiotic recombination. There is also a lack of nucleotide variation on the chromosome. This lack of variation could have been caused by a recent selective sweep, by background selection, or by a combination of these two forces. It should be possible to differentiate between the two mechanisms by studying the frequencies of polymorphic sites on the chromosome: a selective sweep should have resulted in low-frequency polymorphisms, whereas higher frequency polymorphisms would indicate the action of background selection. We have analyzed retrotransposable element insertions on the fourth chromosome in 11 strains of D. melanogaster. The polymorphisms found have a range of frequencies, with the presence of some insertions with high frequencies suggesting that the lack of variation is the result of background selection. We summarize the data using two statistics: the number of sites shared by more than one of the sample of 11 chromosomes (internal sites) and the mean number of transposable element differences in presence or absence between the sampled chromosomes. Simulations indicate that a selective sweep occurring more than 15,000 (0.03N) generations ago cannot be ruled out from the number of internal sites, although the number of differences between the chromosomes suggests either background selection or a sweep occurring more than 60,000 (0.12N) generations ago. Our results show no homoplasies and are thus consistent with no recombination occurring on the chromosome. The difficulties of distinguishing between the models using polymorphism data are discussed.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Schools: School of Applied Sciences
Depositing User: Graham Stone
Date Deposited: 11 Oct 2012 16:01
Last Modified: 11 Oct 2012 16:01
URI: http://eprints.hud.ac.uk/id/eprint/15540

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