Dillon, Michael P., Hayes, Martin A., Simpson, Thomas J. and Sweeney, Joseph B. (1991) The synthesis of isotopically labelled N-acetylcysteamine thioesters utilising a baker's yeast reduction in D2O. Bioorganic & Medicinal Chemistry Letters, 1 (4). pp. 223-226. ISSN 0960-894XMetadata only available from this repository.
Bakers' yeast reduction of ethyl acetoacetate and ethyl 3-oxo-hexanoate in D2O gives the corresponding /gb-hydroxy esters bearing an iosotopic label at the activated methlene position, in good yield and high enantiomeric excess. These compounds have been converted to their N-acetylcysteamine thioesters for use in biosynthetic studies.
|Subjects:||Q Science > QD Chemistry|
|Schools:||School of Applied Sciences|
|Depositing User:||Joseph Sweeney|
|Date Deposited:||09 Oct 2012 10:28|
|Last Modified:||09 Oct 2012 10:28|
Downloads per month over past year
Repository Staff Only: item control page