The synthesis of isotopically labelled N-acetylcysteamine thioesters utilising a baker's yeast reduction in D2O

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Dillon, Michael P., Hayes, Martin A., Simpson, Thomas J. and Sweeney, Joseph B. (1991) The synthesis of isotopically labelled N-acetylcysteamine thioesters utilising a baker's yeast reduction in D2O. Bioorganic & Medicinal Chemistry Letters, 1 (4). pp. 223-226. ISSN 0960-894X

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Official URL: http://dx.doi.org/10.1016/S0960-894X(00)80257-7

DOI: 10.1016/S0960-894X(00)80257-7

Abstract

Bakers' yeast reduction of ethyl acetoacetate and ethyl 3-oxo-hexanoate in D2O gives the corresponding /gb-hydroxy esters bearing an iosotopic label at the activated methlene position, in good yield and high enantiomeric excess. These compounds have been converted to their N-acetylcysteamine thioesters for use in biosynthetic studies.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Joseph Sweeney
Date Deposited:	09 Oct 2012 10:28
Last Modified:	09 Oct 2012 10:28
URI:	http://eprints.hud.ac.uk/id/eprint/15420

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