Ring-opening of n-tosyl aziridines by sulfur-stabilized nucleophiles

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Osborn, Helen, Howson, William and Sweeney, Joseph B. (1993) Ring-opening of n-tosyl aziridines by sulfur-stabilized nucleophiles. Synlett, 9. pp. 675-676. ISSN 0936-5214

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Official URL: http://dx.doi.org/10.1055/s-1993-22568

DOI: 10.1055/s-1993-22568

Abstract

The novel ring-opening reaction of enantiopure N-activated aziridines 1 with anions 2 derived from 1,3-dithiane proceeds regiospecifically at the carbon of lesser substitution. The ring-opened products 3 may efficiently be converted to homochiral 2-tosylaminocarbonyl compounds 4.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Joseph Sweeney
Date Deposited:	17 Oct 2012 12:45
Last Modified:	17 Oct 2012 12:45
URI:	http://eprints.hud.ac.uk/id/eprint/15414

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