A Low-Temperature Ammonium Ylid Rearrangement: Enhanced Reactivity Engendered by Rigidity

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Sweeney, Joseph B. and Sançon, Julien (2008) A Low-Temperature Ammonium Ylid Rearrangement: Enhanced Reactivity Engendered by Rigidity. Synlett, 2008 (14). pp. 2213-2214. ISSN 0936-5214

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Official URL: http://dx.doi.org/10.1055/s-2008-1078256

DOI: 10.1055/s-2008-1078256

Abstract

Sigmatropic rearrangement of tetrahydropyridine-derived ammonium is a valuable method for the preparation of substituted prolines. These reaction normally require elevated temperatures to proceed, but bicyclic tetrahydropyridine-like ylid 1 undergoes rearrangement at -15 ˚C; the extra rigidity of the azabicyclo[3.3.0]octene system preorganizes the transition state and lowers the activation energy for rearrangement.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Joseph Sweeney
Date Deposited:	18 Oct 2012 12:35
Last Modified:	18 Oct 2012 12:35
URI:	http://eprints.hud.ac.uk/id/eprint/15211

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