Goldberg, Kristin, Groombridge, Sam, Hudson, Julian, Leach, Andrew G., MacFaul, Philip A., Pickup, Adrian, Poultney, Ruth, Scott, James S., Svensson, Per H. and Sweeney, Joseph B. (2012) Oxadiazole isomers: all bioisosteres are not created equal. MedChemComm, 3 (5). p. 600. ISSN 2040-2503Metadata only available from this repository.
Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.
|Subjects:||Q Science > QD Chemistry|
R Medicine > RM Therapeutics. Pharmacology
|Schools:||School of Applied Sciences|
|Depositing User:||Joseph Sweeney|
|Date Deposited:||18 Oct 2012 13:16|
|Last Modified:||18 Oct 2012 13:16|
Item control for Repository Staff only: