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Goldberg, Kristin, Groombridge, Sam, Hudson, Julian, Leach, Andrew G., MacFaul, Philip A., Pickup, Adrian, Poultney, Ruth, Scott, James S., Svensson, Per H. and Sweeney, Joseph B. (2012) Oxadiazole isomers: all bioisosteres are not created equal. MedChemComm, 3 (5). p. 600. ISSN 2040-2503
Metadata only available from this repository.Official URL: http://dx.doi.org/10.1039/c2md20054f
DOI: 10.1039/c2md20054f
Abstract
Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Schools: | School of Applied Sciences |
| Related URLs: | |
| Depositing User: | Joseph Sweeney |
| Date Deposited: | 18 Oct 2012 13:16 |
| Last Modified: | 18 Oct 2012 13:16 |
| URI: | http://eprints.hud.ac.uk/id/eprint/15206 |
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