Afrasiabi, Zahra, Sinn, Ekk, Kulkarni, Prasad P., Ambike, Vinita, Padhye, Subhash, Deobagakar, Deepti, Heron, B. Mark, Gabbutt, Christopher D., Anson, Christopher E. and Powell, Annie K. (2005) Synthesis and characterization of copper(II) complexes of 4-alkyl/aryl-1,2-naphthoquinones thiosemicarbazones derivatives as potent DNA cleaving agents. Inorganica Chimica Acta, 358 (6). pp. 2023-2030. ISSN 0020-1693Metadata only available from this repository.
Copper (II) complexes of some alkyl/aryl-1,2 naphthoquinones thiosemicarbazone have been prepared and characterized. The crystal structure determined for one of the free ligands viz. 4-Pyrrolidine-1-yl-[1, 2] naphthaquinone thiosemicarbazone (5) indicates it to crystallize in the “E’ conformation which is supported by the NMR data. The ligands and copper complexes were evaluated for their DNA cleaving activities in case of circular double stranded plasmid DNA pBR322 under aerobic conditions. Amongst the ligands, compound 8 shows almost quantitative conversion to the linearized DNA in presence of H2O2 oxidant. All copper conjugates show more pronounced interaction with DNA while compounds 3 and 7 are able to yield linearized DNA in presence of the oxidant.
|Subjects:||Q Science > Q Science (General)
Q Science > QD Chemistry
|Schools:||School of Applied Sciences|
|Depositing User:||Sharon Beastall|
|Date Deposited:||25 Sep 2012 12:18|
|Last Modified:||18 Oct 2012 08:46|
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