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The effect of prolonged storage at different temperatures on the particle size distribution of tripolyphosphate (TPP)-chitosan nanoparticles

Morris, Gordon, Castile, Jonathan, Smith, Alan, Adams, Gary and Harding, Stephen E. (2011) The effect of prolonged storage at different temperatures on the particle size distribution of tripolyphosphate (TPP)-chitosan nanoparticles. Carbohydrate Polymers, 84 (4). pp. 1430-1434. ISSN 0144-8617

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Chitosan nanoparticles prepared by ionotropic gelation with the tripolyphosphate (TPP) polyanion have been widely considered for drug delivery. The stability (shelf-life) of TPP-chitosan nanoparticles is highly relevant to its potential use as a drug delivery agent as this plays an important role in the function of the nanoparticle and will determine shelf-life. In the present study, the physical stability (in terms of particle size) of TPP-chitosan nanoparticles was measured across a range of different temperature conditions: 4 °C, 25 °C and 40 °C using differential sedimentation. After 12 months storage at 4 and 25 °C the size of nanoparticles remained similar to those of the freshly prepared samples, whilst after storage at 40 °C there were little or no TPP-chitosan nanoparticles remaining after only 6 months. This may be due to the decrease in molar mass of the chitosan possibly due to hydrolysis causing scission of the polymer chains, which results in a decrease in nanoparticle size and eventual disintegration. This mechanism is important in the application of TPP-chitosan as a drug delivery agent. © 2011 Elsevier Ltd. All rights reserved.

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Item Type: Article
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers Volume 84, Issue 4, 2 April 2011, Pages 1430–1434
Uncontrolled Keywords: Chitosan nanoparticles Degradation Particle size Stability Tripolyphosphate (TPP) Ionotropic gelation Nanoparticle sizes Physical stability Polyanions Polymer chains Shelf life Temperature conditions Tripolyphosphates Chitin Chitosan Coagulation Drug delivery Gelation Particle size analysis Nanoparticles
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Gordon Morris
Date Deposited: 13 Sep 2012 14:38
Last Modified: 22 Aug 2015 22:18

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