Morris, Gordon, Castile, Jonathan, Smith, Alan, Adams, Gary and Harding, Stephen E. (2010) The effect of different storage temperatures on the physical properties of pectin solutions and gels. Polymer Degradation and Stability, 95 (12). pp. 2670-2673. ISSN 0141-3910
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Abstract
The stability (in terms of viscosity and gel strength) of pectin solutions and gels potentially plays an important role in their behaviour and functional properties in a wide range of applications and therefore any changes over time must be understood. The gel strength of pectin gels and intrinsic viscosity of pectin solutions at different temperatures (4 °C, 25 °C and 40 °C) have been investigated using a "rolling ball" viscometer and a texture analyser respectively. Both the intrinsic viscosity ([η]) and gel strength decrease with increased storage time, although this more pronounced at elevated temperatures. The changes in intrinsic viscosity with storage time and temperature were used to determine the depolymerisation constant (k). Pectin storage conditions and particularly temperature have an influence on depolymerisation, particularly elevated storage temperatures, but whether or not this will be detrimental to its intended application will depend on the functional significance of the changes that occur. In this case based on the previous diffusion studies on a model drug (paracetamol) we conclude that the decreases in viscosity and gel strength within the range observed have no detrimental effect on the drug release properties.© 2010 Elsevier Ltd. All rights reserved.
▼ Jump to Download Statistics| Item Type: | Article |
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| Additional Information: | NOTICE: this is the author’s version of a work that was accepted for publication in Polymer Degradation and Stability Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Polymer Degradation and Stability Volume 95, Issue 12, December 2010, Pages 2670–2673 |
| Uncontrolled Keywords: | Drug release Gel strength Intrinsic viscosity Molar mass Pectin Stability Case based Detrimental effects Diffusion studies Drug release properties Elevated temperature Functional properties Gel strengths Model drugs Paracetamol Rolling balls Storage condition Storage temperatures Storage time Drug products Gels Viscometers Viscosity |
| Subjects: | Q Science > QD Chemistry |
| Schools: | School of Applied Sciences |
| Related URLs: | |
| References: | Language of Original Document: English |
| Depositing User: | Gordon Morris |
| Date Deposited: | 13 Sep 2012 15:28 |
| Last Modified: | 13 Sep 2012 15:28 |
| URI: | http://eprints.hud.ac.uk/id/eprint/14603 |
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