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Complete Mitochondrial Genome Sequence of the Tyrolean Iceman

Ermini, Luca, Olivieri, Cristina, Rizzi, Ermanno, Corti, Giorgio, Bonnal, Raoul, Soares, Pedro, Luciani, Stefania, Marota, Isolina, De Bellis, Gianluca and Richards, Martin B. (2008) Complete Mitochondrial Genome Sequence of the Tyrolean Iceman. Current Biology, 18 (21). pp. 1687-1693. ISSN 09609822

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Abstract

The Tyrolean Iceman was a witness to the NeolithicCopper Age transition in Central Europe 53505100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QH Natural history > QH426 Genetics
Schools: School of Applied Sciences
Depositing User: Sara Taylor
Date Deposited: 02 Aug 2012 15:54
Last Modified: 02 Aug 2012 15:54
URI: http://eprints.hud.ac.uk/id/eprint/14447

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