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Mitochondrial footprints of human expansions in Africa.

Watson, E., Forster, P., Richards, Martin B. and Bandelt, Hans-Jurgen (1997) Mitochondrial footprints of human expansions in Africa. American Journal of Human Genetics, 61. pp. 691-704. ISSN 1537-6605

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Abstract

mtDNA studies support an African origin for modern Eurasians, but expansion events within Africa have not previously been investigated. We have therefore analyzed 407 mtDNA control-region sequences from 13 African ethnic groups. A number of sequences (13%) were highly divergent and coalesced on the "mitochondrial Eve" in Africans. The remaining sequences also ultimately coalesced on this sequence but fell into four major clusters whose starlike phylogenies testify to demographic expansions. The oldest of these African expansions dates to approximately 60,000-80,000 years ago. Eurasian sequences are derived from essentially one sequence within this ancient cluster, even though a diverse mitochondrial pool was present in Africa at the time.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Schools: School of Applied Sciences
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Depositing User: Sara Taylor
Date Deposited: 26 Jul 2012 13:32
Last Modified: 26 Jul 2012 13:32
URI: http://eprints.hud.ac.uk/id/eprint/14396

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