Gill, Duncan M. (2012) Stereoselective synthesis of a dialkylhydantoin featuring an asymmetric Strecker reaction on an acyclic dialkyl ketone. Tetrahedron Letters, 53 (15). pp. 1951-1953. ISSN 0040-4039
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A diastereoselective Strecker reaction using (R)-(-)-phenylglycinol forms the basis of a concise scalemic route to dialkylhydantoin 1. The phenylglycinol functionality was exploited in the manipulation of the aminonitrile Strecker product through to the dialkylhydantoin via a short, efficient sequence involving crystalline intermediates.
|Subjects:||Q Science > QD Chemistry|
|Schools:||School of Applied Sciences|
|Depositing User:||Duncan Gill|
|Date Deposited:||07 Jun 2012 10:16|
|Last Modified:||17 Oct 2012 11:59|
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