Gill, Duncan M., Taylor, Nicholas H. and Thomas, Eric J. (2011) Synthesis of 2,6-cis-disubstituted 4-methylenetetrahydropyrans by oxy-Michael addition. Tetrahedron, 67 (27-28). pp. 5034-5045. ISSN 0040-4020
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The combination of an ‘ene’ reaction between a 2-(2-trialkylsilyloxyalkyl)prop-2-enyl(trimethyl)silane and an alk-1-yn-3-one mediated by zinc(II) iodide, and an intramolecular oxy-Michael reaction, provides an efficient synthesis of cis-2,6-disubstituted 4-methylenetetrahydropyrans of interest in the context of a synthesis of bryostatins. The stereoselective formation of (E)-vinylsilanes in the ‘ene’ reaction is of interest.
|Subjects:||Q Science > QD Chemistry|
|Schools:||School of Applied Sciences|
|Depositing User:||Duncan Gill|
|Date Deposited:||01 Jun 2012 10:20|
|Last Modified:||17 Oct 2012 12:05|
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