Waters, Laura J. (2010) Micellar Chromatographic Partition Coefficients - an Alternative to Tradition. Journal of Pharmacy and Pharmacology, 62. pp. 1211-1212. ISSN 0022-3573Metadata only available from this repository.
Classically, partition coefficients are determined using octanol and water (Pow) to mimic movement of drugs through biological membranes. An alternative system is proposed using chromatography to determine micelle/water partition coeffi cients (Pmw) for pharmaceutical compounds. It is proposed that using a micellar system provides an interesting alternative to the traditional method that is experimentally faster, equally precise yet most importantly achieves a higher level of accuracy when attempting to correlate with an in vivo situation. This work initially focuses on four drugs with a comparative study between literature Pow and measured Pmw values, this is followed by a comparative study of column and surfactant selection.
|Additional Information:||Paper presented at UK-PharmSci 2010: The Science of Medicines, Nottingham, UK, 1st - 3rd September 2010.|
|Subjects:||Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
|Schools:||School of Applied Sciences|
|Depositing User:||Cherry Edmunds|
|Date Deposited:||20 Feb 2012 11:43|
|Last Modified:||20 Feb 2012 11:45|
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