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Micellar Chromatographic Partition Coefficients - an Alternative to Tradition

Waters, Laura J. (2010) Micellar Chromatographic Partition Coefficients - an Alternative to Tradition. Journal of Pharmacy and Pharmacology, 62. pp. 1211-1212. ISSN 0022-3573

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Abstract

Classically, partition coefficients are determined using octanol and water (Pow) to mimic movement of drugs through biological membranes. An alternative system is proposed using chromatography to determine micelle/water partition coeffi cients (Pmw) for pharmaceutical compounds. It is proposed that using a micellar system provides an interesting alternative to the traditional method that is experimentally faster, equally precise yet most importantly achieves a higher level of accuracy when attempting to correlate with an in vivo situation. This work initially focuses on four drugs with a comparative study between literature Pow and measured Pmw values, this is followed by a comparative study of column and surfactant selection.

Item Type: Article
Additional Information: Paper presented at UK-PharmSci 2010: The Science of Medicines, Nottingham, UK, 1st - 3rd September 2010.
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
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Depositing User: Cherry Edmunds
Date Deposited: 20 Feb 2012 11:43
Last Modified: 20 Feb 2012 11:45
URI: http://eprints.hud.ac.uk/id/eprint/12800

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