Search:
Computing and Library Services - delivering an inspiring information environment

Segregation of Formulated Bulk Powders due to Electrostatic Effects

Šupuk, Enes, Hassanpour, Ali and Ghadiri, Mojtaba (2010) Segregation of Formulated Bulk Powders due to Electrostatic Effects. In: World Congress on Particle Technology WCPT6, 26 April - 29 April 2010, Nuremberg, Germany.

[img]
Preview
PDF - Published Version
Download (70kB) | Preview
    [img] Microsoft Word - Published Version
    Restricted to Repository staff only

    Download (153kB)

      Abstract

      Particle electrification is a common phenomenon that occurs in many powder handling industries such as pharmaceuticals and detergents etc. The unit operations involved in the manufacture of pharmaceutical formulations frequently subject particles to frictional sliding and impact against processing surfaces, giving rise to tribo-electric charging. Pharmaceutical materials, in particular, are susceptible to electrostatic charging due to their low bulk density, small particle size and often irregular shape and electrically insulating nature. The electrostatic charge may cause particles to adhere to container surfaces leading to a loss of powder through deposition; however the problem often extends further and affects the end products’ quality. Segregation can also occur when powders have been subjected to tribo-electrification. In this paper we investigate whether such adhesion resulting from the electrostatic charging could give rise to the segregation of components within a binary mixture. Binary mixtures comprising of α-lactose monohydrate (α-LM) and hydroxypropyl cellulose (HPC) were firstly tribo-charged and then the wall adhered particles were separated by a selective dissolution of one component and the filtration of the non-dissolving component, followed by a gravimetric analysis. The findings reveal that a considerable level of segregation can take place on the wall-adhered particles.

      Item Type: Conference or Workshop Item (Paper)
      Uncontrolled Keywords: segregation electrostatics pharmaceutical
      Subjects: Q Science > Q Science (General)
      Q Science > QC Physics
      Q Science > QD Chemistry
      R Medicine > RS Pharmacy and materia medica
      Schools: School of Applied Sciences
      Related URLs:
      Depositing User: Enes Supuk
      Date Deposited: 26 Jan 2012 16:09
      Last Modified: 26 Jan 2012 16:13
      URI: http://eprints.hud.ac.uk/id/eprint/12602

      Document Downloads

      Downloader Countries

      More statistics for this item...

      Item control for Repository Staff only:

      View Item

      University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©