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Grewia Gum 2: Mucoadhesive Properties of Compacts and Gels

Nep, Elijah I and Conway, Barbara R (2011) Grewia Gum 2: Mucoadhesive Properties of Compacts and Gels. Tropical Journal of Pharmaceutical Research, 10 (4). pp. 393-401. ISSN 1596-5996

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    Purpose: To compare the mucoadhesive performance of grewia polysaccharide gum with those of guar
    gum, carboxymethylcellulose, hydroxypropyl methylcellulose and carbopol 971P.
    Methods: Grewia polysaccharide gum compacts or gels as well as those of guar gum,
    carboxymethylcellulose, hydroxypropyl methylcellulose or carbopol 971P were prepared. Texturometric
    and tensile analysis of the polymer gels and compacts were carried out using a software-controlled
    penetrometre, TA.XTPlus texture analyzer. The polymer gels were evaluated for hardness, stickiness,
    work of cohesion and work of adhesion. Furthermore, the detachment force of the polymer compacts
    from a mucin substrate was evaluated.
    Results: The work of adhesion of guar gels was significantly greater than that of grewia gels (p < 0.001)
    but the latter showed a significantly greater work of adhesion than carboxymethylcellulose gels (p <
    0.05) and hydroxypropyl methylcellulose gels (p < 0.001). However, the work of cohesion for
    grewia/mucin gel mixture was significantly greater (p < 0.001) than those of
    carboxymethylcellulose/mucin, hydroxypropyl methylcellulose/mucin and carbopol 971P/mucin gel
    blends. The difference between the mucoadhesive performance of grewia compacts and those of
    hydroxypropyl methylcellulose and carbopol 971P compacts was insignificant (p > 0.05).
    Conclusion: Grewia polysaccharide gum demonstrated good mucoadhesive properties, comparable to
    those of carbopol 971P, carboxymethylcellulose, guar gum and hydroxypropyl methylcellulose, and
    therefore, should be suitable for the formulation of retentive drug delivery devices.

    Item Type: Article
    Subjects: Q Science > Q Science (General)
    Q Science > QD Chemistry
    Schools: School of Applied Sciences
    Related URLs:
    Depositing User: Sara Taylor
    Date Deposited: 18 Oct 2011 11:54
    Last Modified: 18 Oct 2011 11:54


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